Related Experiment Video

Updated: Dec 23, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.0K

Computer-aided designing of oncolytic viruses for overcoming translational challenges of cancer immunotherapy

Anjali Lathwal1, Rajesh Kumar2, Gajendra P S Raghava1

  • 1Department of Computational Biology, Indraprastha Institute of Information Technology, Delhi, India.

Drug Discovery Today
|April 29, 2020
PubMed

Insights

Computational strategies can enhance oncolytic virus (OV) therapy for cancer. By predicting key viral components, these methods aim to improve OV delivery, spread, and immune response, overcoming common treatment challenges.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy
  • Bioinformatics

Background:

  • Oncolytic viruses (OVs) are promising cancer immunotherapy agents currently in clinical trials.
  • OV therapy faces challenges including viral delivery, spread, immune response, and tumor resistance.

Purpose of the Study:

  • To propose computational strategies for enhancing oncolytic virus (OV) therapy.
  • To address limitations in current OV treatment approaches.

Main Methods:

  • Predicting and prioritizing tumor-homing peptides.
  • Identifying anticancer peptides and neoantigens.
  • Analyzing miRNA response elements within the viral genome.

Main Results:

  • Computational approaches offer solutions to improve OV safety and efficacy.
  • Strategies can enhance viral delivery, spread, and oncolysis.
  • Improved prediction of therapeutic targets can boost antitumor immune responses.

Conclusions:

  • Combining computational methods with genetic engineering can significantly advance OV therapy.
  • These integrated strategies promise safer, more effective oncolytic virotherapy for cancer treatment.

More Related Videos

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

9.4K
Ex Vivo Infection of Live Tissue with Oncolytic Viruses12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

13.0K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
870
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.7K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.8K