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Infective endocarditis in children with congenital heart disease: the changing spectrum, 1965-85

T Geva1, M Frand

  • 1Department of Pediatrics C, Chaim Sheba Medical Centre, Tel-Hashomer, Israel.

European Heart Journal
|November 1, 1988
PubMed

Insights

Infective endocarditis in children with congenital heart disease decreased over time, with improved diagnosis and treatment. Early surgical correction of heart defects is recommended for prevention.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Cardiovascular Surgery

Background:

  • Infective endocarditis (IE) is a serious complication in children with congenital heart disease (CHD).
  • Understanding trends in IE incidence and outcomes is crucial for improving patient care.

Purpose of the Study:

  • To review trends in infective endocarditis in children with congenital heart disease over a 20-year period.
  • To identify changes in incidence, diagnosis, treatment, and outcomes.

Main Methods:

  • Retrospective review of 35 cases of infective endocarditis in children with CHD from 1965 to 1984.
  • Analysis of epidemiological data, clinical presentation, diagnostic methods, pathogens, and outcomes.

Main Results:

  • Incidence of IE in cyanotic CHD increased, while left-to-right shunt lesions decreased.
  • Postoperative endocarditis incidence significantly decreased over the two decades.
  • Diagnosis and treatment time shortened, with 100% positive blood cultures in the latter decade.
  • Echocardiography detected vegetations in 70% of cases; Streptococcus viridans was the most common pathogen.

Conclusions:

  • Significant improvements in the diagnosis and treatment of infective endocarditis in children with CHD were observed.
  • Early surgical correction of congenital heart disease may be the most effective preventive strategy.

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