Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological changes in human breast cancer.

O Contreras Ortiz1, A Stoliar

  • 1SEGBA Gynecology Department - Buenos Aires, Argentina.

European Journal of Gynaecological Oncology
|January 1, 1988
PubMed
Summary

This study shows that breast cancer significantly impacts immune function, particularly T lymphocytes and phytohemagglutinin response, persisting long after surgery in advanced stages. Immune recognition of tumor antigens also declines over time.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress urinary incontinence in the gynecological practice.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2004
Same author

Use of GnRH analogs for functional protection of the ovary and preservation of fertility during cancer treatment in adolescents: a preliminary report.

Gynecologic oncology·2001
Same author

Automated image analysis for monitoring oxidative burst in macrophages.

Analytical and quantitative cytology and histology·2000
Same author

Dynamic assessment of pelvic floor function in women using the intravaginal device test.

International urogynecology journal and pelvic floor dysfunction·1996
Same author

[Deep pudendal reflex].

Medicina·1994
Same author

Pudendal reflexes in women with pelvic floor disorders.

Zentralblatt fur Gynakologie·1994

Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Breast cancer significantly alters immune system parameters.
  • Understanding these changes is crucial for patient prognosis and treatment strategies.

Purpose of the Study:

  • To evaluate key immune system parameters in breast cancer patients over an 18-month period post-surgery.
  • To assess the impact of breast cancer stage on immune function.

Main Methods:

  • Immunological assessments included T lymphocytes, killer cells, phytohemagglutinin response, and leukocyte migration inhibition tests.
  • Phagocytosis and intracellular killing of Candida albicans were also evaluated.
  • Data collected pre-surgery and at 3-month intervals for 18 months from 38 patients.

Main Results:

  • Stage I patients showed minimal immune differences compared to controls.
  • Active T lymphocytes and phytohemagglutinin response were significantly reduced in stages II, III, and IV.
  • Tumor antigen recognition persisted for 6 months in Stage I and throughout the study in advanced stages. Intracellular killing capacity was impaired at 3 months post-surgery.

Conclusions:

  • Breast cancer, especially in advanced stages, leads to a sustained decline in cellular immunity.
  • Immune monitoring post-surgery is essential to understand long-term effects and potential therapeutic targets.

Related Experiment Videos