Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nephrotoxicity associated with ifosfamide.

J Smeitink1, M Verreussel, C Schröder

  • 1Department of Paediatrics, University Hospital, Nijmegen, The Netherlands.

European Journal of Pediatrics
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel mitochondrial <i>ATP8</i> gene mutation in a patient with apical hypertrophic cardiomyopathy and neuropathy.

BMJ case reports·2025
Same author

Identification and characterization of repeat expansions in neurological disorders: Methodologies, tools, and strategies.

Revue neurologique·2024
Same author

Validation and discussion of clinical practicability of the 2022 graded prognostic assessment for NSCLC adenocarcinoma patients with brain metastases in a routine clinical cohort.

Frontiers in oncology·2023
Same author

French Sleepiness Scale for Adolescents-8 items: A discriminant and diagnostic validation.

L'Encephale·2022
Same author

Rewetting does not return drained fen peatlands to their old selves.

Nature communications·2021
Same author

High-dose re-irradiation of intracranial lesions - Efficacy and safety including dosimetric analysis based on accumulated EQD2Gy dose EQD calculation.

Clinical and translational radiation oncology·2021
Same journal

Long-term recurrence and acute seizure clustering in children with convulsions with mild gastroenteritis: a systematic review and meta-analysis.

European journal of pediatrics·2026
Same journal

Cost-benefit analysis of nirsevimab for respiratory syncytial virus prevention in infants: a population-based study.

European journal of pediatrics·2026
Same journal

Consensus statement on the use of standardized early mobilization in pediatric patients admitted to pediatric intensive care units in Italy.

European journal of pediatrics·2026
Same journal

Ultrasound-guided midline catheters in the neonatal intensive care unit: a single-center pilot study.

European journal of pediatrics·2026
Same journal

Gastrointestinal pathogens in paediatric patients with diarrhoea during the COVID-19 pandemic in Spain: a multicentre molecular-based prospective study.

European journal of pediatrics·2026
Same journal

Low serum immunoglobulin levels in pediatric atopic dermatitis: association with disease severity and exploratory scores.

European journal of pediatrics·2026
See all related articles

Ifosfamide treatment can cause irreversible Fanconi syndrome, a kidney disorder, in patients. Early intervention is crucial for managing this condition and its impact on glomerular function.

Area of Science:

  • Nephrology
  • Pediatric Oncology
  • Clinical Pharmacology

Background:

  • Ifosfamide is a widely used chemotherapeutic agent, particularly in pediatric oncology.
  • The SIOP-MMT 84 protocol outlines a specific dosing regimen for ifosfamide treatment.
  • Fanconi syndrome is a generalized proximal tubule disorder affecting renal reabsorption.

Observation:

  • Three patients treated with ifosfamide (3000 mg/m2 every 4 weeks for 10 months) developed Fanconi syndrome.
  • Impairment of glomerular function was noted, with endogenous creatinine clearance between 30-60 ml/min per 1.73 m2.
  • Renal lesions observed in these patients were irreversible.

Findings:

  • Chemotherapy with ifosfamide can induce Fanconi syndrome.
  • Ifosfamide-induced nephrotoxicity may lead to significant glomerular function impairment.

Related Experiment Videos

  • The renal damage associated with this syndrome can be permanent.

    • Implications:

    • Highlights the potential for severe, irreversible nephrotoxicity from ifosfamide therapy.
    • Stresses the critical need for early detection and substitution therapy in patients developing Fanconi syndrome.
    • Underscores the importance of monitoring renal function in patients undergoing prolonged ifosfamide treatment.