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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Metabolomics in Central Sensitivity Syndromes.

Joseph S Miller1, Luis Rodriguez-Saona2, Kevin V Hackshaw3

  • 1Department of Medicine, Ohio University Heritage College of Osteopathic Medicine, Dublin, OH 43016, USA.

Metabolites
|April 30, 2020
PubMed
Summary

Metabolomics shows promise for diagnosing central sensitization syndromes (CSS), a group of painful disorders. Identifying altered metabolites could lead to new treatments and better diagnostics for these challenging conditions.

Keywords:
biomarkercentral sensitivitychronic painfibromyalgiafunctional syndromelaboratory diagnosticsmetabolite profilingmetabolomicsoverlapping syndromespain

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Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Systems Biology

Background:

  • Central sensitization syndromes (CSS) are painful disorders impacting quality of life and increasing opiate abuse risk.
  • Current diagnostic methods for CSS are often unreliable, hindering effective treatment.
  • Identifying key molecular markers is crucial for developing novel therapeutics and precise treatments for CSS.

Purpose of the Study:

  • To review the current applications of metabolomics in understanding central sensitization syndromes.
  • To assess the potential of metabolomics in identifying diagnostic biomarkers for CSS.
  • To explore how metabolomic findings can inform therapeutic strategies for CSS.

Main Methods:

  • Comprehensive literature search of PubMed, Embase, and Scopus databases up to February 2020.
  • Inclusion of cohort studies, case series, and interventional studies involving adult and pediatric CSS patients.
  • Analysis focused on studies utilizing metabolomics to investigate biological samples from individuals with CSS.

Main Results:

  • The majority of reviewed metabolomic studies identified significant metabolite alterations in CSS patients compared to healthy controls.
  • These altered metabolites demonstrated potential for differentiating individuals with CSS.
  • The findings strongly support the utility of metabolomics in the study of CSS.

Conclusions:

  • Metabolomics is a valuable tool for investigating central sensitization syndromes.
  • Further research on identified metabolites and pathways may yield improved diagnostics and therapeutics for CSS.
  • The findings support the integration of metabolomics into CSS research for enhanced patient outcomes.