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Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
Published on: April 22, 2019
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Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study
Pernille Juhl1,2, Anne-Christine Bay-Jensen3, Roger Hesselstrand4
1Department of Biomedical science, Copenhagen University, Copenhagen, Denmark. pju@nordicbio.com.
Scientific Reports
|April 30, 2020
Summary
Systemic sclerosis alters tissue turnover, particularly in the skin. Examining collagen III and VI turnover may help track skin fibrosis and identify patients at risk of progression.
Area of Science:
- Biochemistry
- Dermatology
- Rheumatology
Background:
- Systemic sclerosis (SSc) is characterized by altered tissue turnover and fibrosis, especially in the skin.
- Understanding collagen remodeling is crucial for managing SSc progression.
Purpose of the Study:
- To investigate the turnover of type III, IV, and VI collagens in SSc patients.
- To analyze longitudinal changes in collagen turnover in relation to the modified Rodnan Skin Score (mRSS).
Main Methods:
- Serum biomarkers for collagen formation (PRO-C3, PRO-C4, PRO-C6) and degradation (C3M, C4M, C6M) were measured.
- The fibrotic index for individual collagens (FICol) was calculated for patients with limited cutaneous SSc (lcSSc), diffuse cutaneous SSc (dcSSc), and healthy controls (HC).
Main Results:
- The fibrotic index of type III (FICol3) and type VI (FICol6) collagens were elevated in dcSSc compared to lcSSc.
- FICol3 and FICol6 showed significant correlations with mRSS.
- FICol3 demonstrated a decrease over the course of the disease.
Conclusions:
- Collagen turnover markers, specifically FICol3 and FICol6, are associated with skin fibrosis in SSc.
- Monitoring specific collagen types could aid in patient management and identification of progressive disease.
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