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Clinical characteristics and prognosis of acquired perforating dermatosis: A case report

Mei-Fang Wang1, Xue-Ling Mei1, Li Wang1

  • 1Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.

Experimental and Therapeutic Medicine
|April 30, 2020
PubMed

Insights

Acquired perforating dermatosis (APD) is a rare skin condition linked to systemic diseases. Managing underlying conditions, not just skin symptoms, is key to improving APD outcomes.

Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Acquired perforating dermatosis (APD) is an uncommon skin disease.
  • It presents as umbilicated hyperkeratotic lesions with transepidermal elimination of dermal components.
  • APD is often associated with systemic disorders like chronic renal failure and diabetes mellitus.

Purpose of the Study:

  • To describe four cases of APD.
  • To investigate the clinical characteristics and prognosis of APD.
  • To explore the link between APD and systemic disorders.

Main Methods:

  • Case study of four patients with APD.
  • Analysis of clinical characteristics.
  • Correlation with pre-existing systemic disorders.

Main Results:

  • All four patients had pre-existing systemic disorders before APD onset.
  • Three patients had concurrent renal and thyroid disorders; one had hepatocirrhosis.
  • APD onset followed transient worsening of the systemic disease.
  • Dermatosis symptoms improved upon remission of the systemic disorder without specific dermatological treatment.

Conclusions:

  • Management of associated systemic diseases is crucial for successful APD treatment.
  • APD is closely linked to the status of underlying systemic conditions.
  • Remission of systemic disorders leads to improvement in APD symptoms.
Keywords:
acquired perforating dermatosisclinical characteristicsdermatosis symptomssystemic disorders

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