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Related Experiment Video

Updated: Dec 23, 2025

High Throughput SiRNA Screening for Chloropicrin and Hydrogen Fluoride-Induced Cornea Epithelial Cell Injury

High Throughput SiRNA Screening for Chloropicrin and Hydrogen Fluoride-Induced Cornea Epithelial Cell Injury

Published on: June 16, 2018

Short-term, high-dose hydroxychloroquine corneal toxicity.

Daniel E Savage¹, Ronald Plotnik¹, Rachel A F Wozniak¹

¹Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

American Journal of Ophthalmology Case Reports

|April 30, 2020

Summary

High-dose hydroxychloroquine, used for cancer therapy, can cause vortex keratopathy. While stopping the drug resolves corneal changes, visual impairment may persist, necessitating scleral lenses.

Keywords:

Clinical trial Hydroxychloroquine Vortex keratopathy

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Area of Science:

Ophthalmology
Oncology
Pharmacology

Background:

Hydroxychloroquine is increasingly used as an adjuvant therapy for recurrent breast cancer.
Vortex keratopathy is a known side effect of hydroxychloroquine, typically dose and duration dependent.

Observation:

A 61-year-old female developed significant corneal vortex keratopathy within 3 months of high-dose (1200 mg daily) hydroxychloroquine treatment.
Corneal findings resolved within 1 month of medication cessation, but visual acuity did not fully recover.

Findings:

The patient presented with vortex keratopathy without concurrent retinal pathology.
Persistent irregular astigmatism and ocular surface disease required scleral contact lens management for best-corrected visual acuity of 20/25 OU.

Implications:

Increased use of high-dose hydroxychloroquine in cancer therapy may lead to more frequent cases of vortex keratopathy.
Persistent visual impairment is possible even after medication cessation.
Understanding this condition is crucial for patient counseling and guiding treatment strategies.