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Cutaneous Melanoma - A Review of Systemic Therapies

Karla A Lee, Paul Nathan

    Acta Dermato-Venereologica
    |April 30, 2020
    PubMed

    Insights

    Advanced melanoma patients show improved outcomes with immunotherapy and targeted treatments. While durable responses are possible, further research into emerging strategies is crucial for better melanoma treatment.

    Area of Science:

    • Oncology
    • Dermatology
    • Immunology

    Background:

    • Significant advancements in treating advanced melanoma have emerged this decade.
    • Immunotherapies and targeted treatments have improved patient outcomes across various settings.
    • Complete remission and durable responses are increasingly achievable for metastatic melanoma patients.

    Purpose of the Study:

    • To review current systemic treatment strategies for advanced and recurrent melanoma.
    • To discuss adjuvant and neoadjuvant therapies for cutaneous melanoma.
    • To highlight emerging strategies and ongoing challenges in melanoma treatment.

    Main Methods:

    • Review of current literature on melanoma systemic therapies.
    • Discussion of treatment protocols for unresectable stage III-IV and recurrent melanoma.
    • Analysis of data from adjuvant and neoadjuvant clinical trials.

    Main Results:

    • Immunotherapies and targeted treatments show significant efficacy in advanced melanoma.
    • Approximately 50% improvement in recurrence-free survival observed with adjuvant therapies.
    • Neoadjuvant immunotherapy trials demonstrate promising early results.

    Conclusions:

    • Current treatments offer hope for durable responses and remission in advanced melanoma.
    • Adjuvant and neoadjuvant therapies are improving survival rates.
    • Heterogeneous and non-durable responses necessitate continued research into novel melanoma treatments.
    Keywords:
    immunotherapysystemic therapytargeted therapymelanoma

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