Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.2K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.2K
Experimental RNAi02:15

Experimental RNAi

7.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.2K
RNA Interference01:23

RNA Interference

27.6K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
27.6K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.1K
4.1K
Translational Regulation01:29

Translational Regulation

450
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
450

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Polymer Concentration and Surface Charge on Controllable Nanopesticides Delivery.

Polymers·2026
Same author

[Expectant management versus acetaminophen for early treatment of hemodynamically significant patent ductus arteriosus in very preterm infants: a randomized controlled trial].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2026
Same author

Learning curve and perioperative outcomes: a retrospective cohort study between synchronous and combined inflatable mediastinoscope-laparoscopic radical esophagectomy.

Surgical endoscopy·2026
Same author

Direct Visualization and Regulation of Interfacial Ion Concentration Layer at Zinc Metal Interfaces via an Ion-Buffering Artificial Solid Electrolyte Interphase.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Targeted co-delivery of curcumin and TRAIL via engineered extracellular vesicles: a synergistic therapy against resistant cancers.

Drug delivery and translational research·2026
Same author

Impact of field number and monitor units per segment on magnetic resonance-guided hypofractionated stereotactic radiotherapy for brain metastases: plan quality, deliverability, and robustness trade-offs.

Quantitative imaging in medicine and surgery·2026

Related Experiment Video

Updated: Dec 23, 2025

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
05:28

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Published on: August 15, 2019

25.0K

[Research progress in transdermal delivery for small interfering RNA].

Yu Chen1, Nuo Xu1, Zhenlin Hu2

  • 1College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, Zhejiang, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|April 30, 2020
PubMed
Summary

Small interfering RNA (siRNA) shows promise for skin diseases, but delivery is challenging. This review highlights recent advances in safe and efficient siRNA transdermal delivery vectors for effective treatment.

Keywords:
RNA interferencedelivery vectorlipidosomenanoparticlespolymersskin diseasessmall interfering RNA

More Related Videos

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
10:14

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects

Published on: May 4, 2018

14.3K
Practical Use of RNA Interference: Oral Delivery of Double-stranded RNA in Liposome Carriers for Cockroaches
08:26

Practical Use of RNA Interference: Oral Delivery of Double-stranded RNA in Liposome Carriers for Cockroaches

Published on: May 1, 2018

9.8K

Related Experiment Videos

Last Updated: Dec 23, 2025

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
05:28

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Published on: August 15, 2019

25.0K
Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
10:14

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects

Published on: May 4, 2018

14.3K
Practical Use of RNA Interference: Oral Delivery of Double-stranded RNA in Liposome Carriers for Cockroaches
08:26

Practical Use of RNA Interference: Oral Delivery of Double-stranded RNA in Liposome Carriers for Cockroaches

Published on: May 1, 2018

9.8K

Area of Science:

  • Dermatology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Small interfering RNA (siRNA) is a therapeutic molecule with potential for treating various skin diseases.
  • Current limitations of siRNA include its electronegativity, polarity, susceptibility to degradation, and poor skin penetration.
  • Effective siRNA therapy for skin conditions necessitates safe and efficient delivery vectors.

Purpose of the Study:

  • To review recent advancements in siRNA transdermal delivery vectors.
  • To discuss novel strategies for overcoming skin barrier challenges in siRNA delivery.
  • To highlight the potential of new delivery systems for treating skin diseases.

Main Methods:

  • Literature review of recent research on siRNA delivery systems.
  • Focus on lipid-, polymer-, peptide-, and nanoparticle-based vectors.
  • Analysis of emerging transdermal delivery vectors like liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles.

Main Results:

  • Significant progress has been made in developing diverse siRNA delivery systems.
  • Liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles are promising transdermal vectors.
  • These novel vectors show potential for improved siRNA stability and skin penetration.

Conclusions:

  • Developing advanced siRNA transdermal delivery vectors is crucial for effective skin disease treatment.
  • Recent innovations offer solutions to overcome the inherent challenges of siRNA delivery.
  • Further research into these vectors will advance siRNA-based dermatological therapies.