Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

16.4K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.4K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

26.9K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
26.9K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.4K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.4K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.7K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cryogenic silicification enables nongenetic functional continuity across mammalian cell generations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

An asymptomatic <i>WASF1</i> truncation reveals pathogenic mechanism and therapeutic strategy for neurodevelopmental disorders.

Frontiers in behavioral neuroscience·2026
Same author

Development and validation of a nomogram for predicting recurrence in epithelial ovarian cancer after primary cytoreductive surgery: A single-center retrospective study.

Pakistan journal of medical sciences·2026
Same author

Primary cilia protect against intervertebral disc degeneration and spine scoliosis by regulating Hedgehog-P53-mediated cell apoptosis signaling.

Journal of advanced research·2026
Same author

Prognostic Value of Scoring Systems in Elderly Sepsis-Associated AKI Patients: A Multicenter Retrospective Cohort Study.

Journal of intensive care medicine·2026
Same author

Predicting 28-day and 90-day mortality in microbiologically-confirmed sepsis: a retrospective cohort study.

BMC infectious diseases·2026

Related Experiment Video

Updated: Dec 23, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.3K

Biomimetic self-assembly of subcellular structures.

Shuying Yang1, Lingxiang Jiang1

  • 1College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China. jianglx@jnu.edu.cn.

Chemical Communications (Cambridge, England)
|April 30, 2020
PubMed
Summary

Scientists are exploring hierarchical self-organization for synthetic cell building. Simple synthetic systems mimic cell structures and functions, highlighting the power of physicochemical mechanisms.

Area of Science:

  • Biophysics
  • Synthetic Biology
  • Materials Science

Background:

  • Living cells exhibit complex architecture and function through self-organization.
  • Understanding the fundamental principles of cellular self-assembly is crucial for synthetic biology.
  • Current research focuses on mimicking biological structures using simplified systems.

Purpose of the Study:

  • To review recent advancements in synthetic self-assembly of cell-like structures.
  • To highlight the role of fundamental physicochemical mechanisms in biological self-organization.
  • To outline future directions in creating functional synthetic cells.

Main Methods:

  • Summarizing research on synthetic self-assembly of subcellular structures.
  • Analyzing systems including flattened sacs, crystalline membranes, coacervate droplets, filaments, and asters.

More Related Videos

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

6.5K
Self-Assembly of Microtubule Tactoids
08:49

Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

4.4K

Related Experiment Videos

Last Updated: Dec 23, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.3K
Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

6.5K
Self-Assembly of Microtubule Tactoids
08:49

Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

4.4K
  • Focusing on systems with minimal molecular constituents.

    • Main Results:

    • Synthetic systems can reproduce the architecture and function of biological structures with simplicity.
    • Hierarchical self-organization is a key principle in cellular construction.
    • Physicochemical mechanisms are more critical than specific molecular details in these systems.

    Conclusions:

    • Simple synthetic systems effectively mimic complex biological structures and functions.
    • Fundamental physicochemical principles drive self-organization in both natural and synthetic systems.
    • Future research will focus on integrating assembled structures for synergistic function towards cell imitation.