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Related Experiment Videos

Papain anaphylaxis: a case report.

H B Freye1

  • 1Department of Medicine, Rhode Island Hospital, Providence.

Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|September 1, 1988
PubMed
Summary

Occupational exposure to Papain can cause severe anaphylaxis, mimicking various diseases. Removing exposure resolved symptoms, highlighting the need for papain allergy testing.

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Area of Science:

  • Allergy and Immunology
  • Occupational Health

Background:

  • Papain, a proteolytic enzyme derived from papaya, is widely used in various industries.
  • Occupational exposure to enzymes can lead to sensitization and allergic reactions.

Observation:

  • A patient presented with recurrent, life-threatening anaphylaxis.
  • Symptoms mimicked rheumatoid, gastrointestinal, cardiac, and pulmonary conditions.
  • Anaphylaxis resolved upon removal from occupational Papain exposure.

Findings:

  • The patient exhibited occupational sensitivity to Papain.
  • Intermittent symptoms were initially misdiagnosed due to their diverse nature.
  • Complete symptom resolution occurred after spatial separation from Papain powder.

Implications:

  • Papain is a significant occupational and environmental contaminant.
  • Clinical practice should include papaya antigen for scratch testing.
  • Early identification of Papain allergy is crucial for preventing severe reactions.

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