Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infection01:20

Infection

11.4K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.4K
Stages of Infection01:26

Stages of Infection

64.5K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.5K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

9.0K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.0K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.3K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.3K
Asepsis01:28

Asepsis

2.7K
The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
2.7K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors for day case surgery in shoulder arthroplasty: a study using the National Joint Registry and Hospital Episode Statistics for England.

Journal of orthopaedic surgery and research·2025
Same author

Outcomes of reverse shoulder arthroplasty as a day case procedure: a population-based cohort study using the National Joint Registry and Hospital Episode Statistics.

Annals of the Royal College of Surgeons of England·2025
Same author

Histological evaluation of cardiac remodelling in equine athletes.

Scientific reports·2024
Same author

Cartiva interpositional arthroplasty versus arthrodesis in the treatment of Hallux rigidus: A retrospective comparative study with mean 2 year follow up.

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2024
Same author

A practical evidence-based approach to management of type 2 diabetes in children and young people (CYP): UK consensus.

BMC medicine·2024
Same author

Anatomical shoulder replacements in young patients: A systematic review and meta-analysis.

Shoulder & elbow·2023
Same journal

A prospective randomised controlled trial comparing open and laparoscopic pyloromyotomy for infantile hypertrophic pyloric stenosis in a low-middle-income country setting.

Annals of the Royal College of Surgeons of England·2026
Same journal

Designing sustainable robotic surgery for NHS scale-up: direct electricity measurement and an implementation-ready energy mitigation bundle in colorectal cancer resections.

Annals of the Royal College of Surgeons of England·2026
Same journal

Trends and causes of litigation in paediatric surgery within the National Health Service (NHS) England: a 19-year analysis.

Annals of the Royal College of Surgeons of England·2026
Same journal

Laparoscopic-assisted ERCP is a safe procedure with good outcomes: experience from a single high-volume upper GI unit.

Annals of the Royal College of Surgeons of England·2026
Same journal

The incidence of complex regional pain syndrome following total knee arthroplasty: a prospective multicentre observational study of 1,026 patients with no cases identified according to the Budapest criteria.

Annals of the Royal College of Surgeons of England·2026
Same journal

Can a generic fracture fixation assessment tool be used to assess quality of distal radius fracture fixation, and predict fixation failure?

Annals of the Royal College of Surgeons of England·2026
See all related articles

Related Experiment Video

Updated: Dec 23, 2025

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection
06:56

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection

Published on: February 20, 2020

9.0K

When infection isn't infection.

S Franklin1, S Sabharwal1, S Hettiaratchy1

  • 1Imperial College Healthcare NHS Trust, London, UK.

Annals of the Royal College of Surgeons of England
|April 30, 2020
PubMed
Summary
This summary is machine-generated.

A proximal humerus fracture patient developed a post-operative infection that did not improve with antibiotics. The rare condition pyoderma gangrenosum was diagnosed, leading to rapid improvement with corticosteroid therapy.

Keywords:
Humeral fractureORIFOpen reduction and internal fixationPyoderma gangrenosum

More Related Videos

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.5K
In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

2.7K

Related Experiment Videos

Last Updated: Dec 23, 2025

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection
06:56

A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection

Published on: February 20, 2020

9.0K
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.5K
In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

2.7K

Area of Science:

  • Orthopedic Surgery
  • Dermatology
  • Infectious Diseases

Background:

  • Open reduction and internal fixation for proximal humerus fractures can lead to complications.
  • Surgical site infections are a common cause of postoperative morbidity.

Observation:

  • A 71-year-old man presented with wound changes and elevated inflammatory markers post-surgery.
  • Initial treatment with antibiotics and debridement was ineffective.
  • Soft tissue breakdown also occurred at a thigh hematoma site.

Findings:

  • The patient's condition did not improve with standard infection protocols.
  • A diagnosis of pyoderma gangrenosum was established.
  • Systemic corticosteroid therapy resulted in rapid clinical improvement.

Implications:

  • Highlights the importance of considering diverse differential diagnoses in complex post-operative cases.
  • Underscores the need for prompt recognition and appropriate management of pyoderma gangrenosum.
  • Suggests a multidisciplinary approach may be beneficial for challenging surgical site complications.