Stimuli-responsive flexible Lewis pair-modified nanoparticles for fluorescence imaging
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Updated: Jun 16, 2026

Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Nicole E Arsenault1, Kathleen T Downey1, Michael O Wolf1
1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada. mwolf@chem.ubc.ca.
Abstract:
A stimuli-responsive fluorophore, encompassing a Lewis acid-base pair, binds to primary amines on mesoporous silica nanoparticles, which may serve as environment-sensitive drug carriers. The fluorophore switches conformation, exhibiting different emission color and lifetimes, allowing for the detection of the water content of the nanoparticles' surroundings through fluorescence spectroscopy and microscopy.
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