Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Arch of Aorta01:10

The Arch of Aorta

1.5K
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endovascular stem cell therapy reconfigures post-stroke ER dynamics via GRP78/Atlastin/CHOP axis.

Molecular brain·2026
Same author

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis.

Annals of clinical and translational neurology·2026
Same author

TDP-43: a critical amplifier of Alzheimer's disease beyond amyloid and tau.

Neuroscience·2026
Same author

IKK-β inhibition as a precision therapeutic approach to disrupt the NF-κB neuroinflammatory cascade in Parkinson's disease.

European journal of pharmacology·2026
Same author

Transcending Social and Cultural Barriers to Transform Global Stroke Care: An SVIN Mission Thrombectomy Initiative.

Stroke (Hoboken, N.J.)·2026
Same author

Mesenchymal Stem cell therapy with GHRH receptor analog resolves post-stroke vasogenic edema via modulating AQP4 and mitochondria-ER crosstalk.

Journal of translational medicine·2026

Related Experiment Video

Updated: Dec 23, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.6K

Migraine and Ischemic Stroke: Deciphering the Bidirectional Pathway.

Swapnil Raut1, Upasna Singh1, Deepaneeta Sarmah1

  • 1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat 382355, India.

ACS Chemical Neuroscience
|April 30, 2020
PubMed
Summary

Migraine with aura (MA) is linked to ischemic stroke, particularly in young women. Understanding the pathways, like cortical spreading depression, is key to preventing migraine-related strokes.

Keywords:
Antimigraine drugsCSDCerebral microembolismEstrogenIschemic strokeMigraine

More Related Videos

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
16:13

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

20.3K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.4K

Related Experiment Videos

Last Updated: Dec 23, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.6K
Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
16:13

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

20.3K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.4K

Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroscience

Background:

  • Migraine and stroke are common neurological disorders with a complex bidirectional relationship.
  • Migraine with aura (MA) is particularly associated with an increased risk of ischemic stroke, especially in young women.
  • Migrainous infarction, a rare complication, often affects the posterior circulation.

Purpose of the Study:

  • To explore the potential pathological pathways linking migraine and stroke.
  • To elucidate the mechanisms underlying migrainous infarction.
  • To identify factors contributing to the migraine-stroke connection.

Main Methods:

  • Review of existing experimental and clinical data.
  • Analysis of proposed mechanisms including cortical spreading depression (CSD).
  • Consideration of genetic, hormonal, hypercoagulation, and cardiac shunt factors.

Main Results:

  • Cortical spreading depression (CSD) is hypothesized as a key factor in migrainous infarction.
  • Other contributing factors include genetics, hormonal fluctuations, hypercoagulation, and cardiac shunts.
  • Certain migraine treatments (ergot alkaloids, triptans) may increase ischemia risk due to vasoconstriction.
  • Cerebral microembolism may trigger MA.

Conclusions:

  • The precise pathological process of migrainous infarction remains unclear.
  • Further research into migraine treatment could reduce stroke incidence.
  • Understanding these pathways is crucial for managing patients with both conditions.