Related Experiment Video
Updated: Dec 23, 2025
Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
Published on: January 27, 2023
The Role of Endostatin in Rheumatoid Arthritis
1Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Background:
Endostatin by its therapeutic value against rheumatoid arthritis has recently gained significant interest in biomedical science. A recent study revealed that various approaches have been made to prevent rheumatoid arthritis by either controlling or inhibiting the progression of angiogenesis.
Objective:
The main objective of the current manuscript is to enumerate the intrinsic role of endostatin in rheumatoid arthritis.
Methods:
A thorough and detailed review of literature from the papers published from the year 1997-2019 was studied for the preparation of the current article.
Results:
Endostatin is one such agent of the subfamily of ECM called as multiplexins obtained from proteolytic cleavage of XVIII and its carboxylic terminal fragments and is known for its antiangiogenic and antiproliferative property. The exact mechanism of endostatin is still unclear, but it acts by downregulating or inhibiting the responses of various factors, including Id1, Id3, matrix metalloproteinase, and Nuclear factor Kappa B that are liable for angiogenesis. The mutual effects on adipogenesis and angiogenesis, endostatin inhibits dietary-induced obesity and its related metabolic disorders, such as insulin resistance, glucose intolerance, and hepatic steatosis.
Conclusion:
The present review demonstrates the intrinsic usage of endostatin as a novel molecule in rheumatoid arthritis. It focuses on the status of the therapeutic potential of endostatin in inhibiting the activity of angiogenesis is also very well explored.
Insights
Endostatin, a potent antiangiogenic agent, shows promise in treating rheumatoid arthritis by inhibiting blood vessel formation. Its therapeutic potential in managing this condition is well-supported by scientific literature.
Area of Science:
- Biomedical Science
- Rheumatology
- Molecular Biology
Background:
- Rheumatoid arthritis (RA) is a significant focus in biomedical science due to its debilitating effects.
- Angiogenesis, the formation of new blood vessels, plays a critical role in RA progression.
- Therapeutic strategies targeting angiogenesis are being explored to prevent or manage RA.
Purpose of the Study:
- To elucidate the specific role of endostatin in the context of rheumatoid arthritis.
- To review the literature on endostatin's mechanisms and therapeutic potential for RA.
Main Methods:
- Comprehensive literature review of studies published between 1997 and 2019.
- Analysis of research on endostatin's antiangiogenic and antiproliferative properties.
- Examination of endostatin's molecular targets and pathways involved in angiogenesis.
Main Results:
- Endostatin, derived from collagen XVIII, exhibits significant antiangiogenic and antiproliferative effects.
- It functions by downregulating key factors involved in angiogenesis, such as Id1, Id3, matrix metalloproteinase, and Nuclear factor Kappa B.
- Endostatin also influences adipogenesis, potentially mitigating metabolic disorders associated with obesity.
Conclusions:
- Endostatin presents as a novel therapeutic molecule for rheumatoid arthritis.
- Its capacity to inhibit angiogenesis is a key factor in its potential application for RA treatment.
- Further exploration of endostatin's therapeutic efficacy in RA is warranted.
Related Concept Videos
01:20The JAK-STAT Signaling Pathway
01:17Role of ER in the Secretory Pathway
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
01:24T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:23Rheumatic Heart Disease I: Introduction
01:15Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...