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Updated: Dec 23, 2025

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Novel application of a calcium silicate‒based cement and platelet-rich fibrin in complex endodontic cases: a case
Abstract:
Three-dimensional sealing of root canals is essential for long-term endodontic success. It is sometimes difficult to achieve a fluid-tight seal in cases such as furcation defects, resorption lesions, open apices, and root fractures. Such cases require restorative materials that not only are biocompatible and well accepted by the surrounding periodontium but also will set in the wet oral environment without losing their properties. This case series describes management of an open apex, a furcal perforation, and a horizontal root fracture with a bioactive calcium silicate‒based cement (Biodentine) as root repair material. To prevent extrusion of the cement, platelet-rich fibrin was used as an external matrix. The patients were followed for 2-3 years, and the teeth demonstrated remarkable healing.
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