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Correlation between Heart fatty acid binding protein and severe COVID-19: A case-control study
Li Yin1, Huaming Mou1, Jiang Shao1
1Department of Cardiology, Heart Center, Chongqing Three Gorges Central Hospital, Affiliated Three Gorges Hospital of Chongqing University, Chongqing, China.
Plos One
|April 30, 2020
Summary
Elevated heart-fatty acid binding protein (HFABP) levels correlate with COVID-19 severity. This marker may predict rapid progression from mild to severe COVID-19 cases, though it did not impact mortality.
Area of Science:
- Biochemistry
- Cardiology
- Infectious Diseases
Background:
- Heart-fatty acid binding protein (HFABP) is a known heart-specific marker.
- The relationship between HFABP and COVID-19 severity was previously unexplored.
Purpose of the Study:
- To investigate the correlation between HFABP levels and COVID-19 severity.
- To determine if HFABP can predict disease progression in COVID-19 patients.
Main Methods:
- Retrospective analysis of 46 COVID-19 patients.
- HFABP levels were measured upon diagnosis and monitored during hospitalization.
- Statistical analysis, including chi-square tests and odds ratios, was used to assess correlation.
Main Results:
- 16 out of 46 patients had HFABP > 7 ng/mL upon admission.
- 14 of these 16 patients developed severe COVID-19.
- Elevated HFABP showed an odds ratio of 6.81 for severe COVID-19.
Conclusions:
- Elevated HFABP is closely linked to COVID-19 severity.
- Increased HFABP may indicate a risk of rapid progression to severe disease.
- Negative serum HFABP suggests a potentially safer prognosis for mild COVID-19 cases, with no observed effect on mortality.
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