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Management of Behcet's syndrome
Omer Karadag1,2, Ertugrul Cagri Bolek1,2
1Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Rheumatology (Oxford, England)
|April 30, 2020
Summary
Behcet's syndrome (BS) is a complex vasculitis requiring multidisciplinary management. While corticosteroids are primary, other agents and biologics are used, with ongoing research for better treatments.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Behcet's syndrome (BS) is a systemic vasculitis with diverse clinical manifestations.
- While skin, joint, and mucosal issues impact quality of life, untreated ocular, vascular, neurological, and gastrointestinal involvement can be fatal.
- Multidisciplinary team management is crucial for timely diagnosis and integrated treatment.
Purpose of the Study:
- To review the current understanding and management of Behcet's syndrome.
- To highlight the role of various therapeutic agents and identify unmet needs in BS treatment.
Main Methods:
- Literature review of Behcet's syndrome management strategies.
- Analysis of current therapeutic options including corticosteroids, conventional immunosuppressants, and biologic agents.
- Discussion of emerging treatments and the need for comparative studies.
Main Results:
- Corticosteroids remain the cornerstone of Behcet's syndrome therapy.
- A range of immunosuppressants (e.g., colchicine, azathioprine) and biologics (e.g., TNF inhibitors) are utilized for induction and maintenance.
- Significant unmet needs persist, necessitating further research and head-to-head treatment comparisons.
Conclusions:
- Effective management of Behcet's syndrome relies on a multidisciplinary approach.
- Current therapies address various manifestations, but novel agents are anticipated to improve future care standards.
- Further comparative studies are essential to optimize treatment algorithms for Behcet's syndrome.
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