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Updated: Dec 23, 2025

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
Published on: August 22, 2025
A phased approach to implementing the Breast Imaging Reporting and Data System (BI-RADS) in low-income and
Diana L Lam1, Pegah Entezari1, Catherine Duggan2
1Department of Radiology, Seattle Cancer Care Alliance, University of Washington, Seattle, Washington.
Background:
Successful breast cancer detection programs rely on standardized reporting and interpreting systems, such as the Breast Imaging Reporting and Data System (BI-RADS), to improve system performance. In low-income and middle-income countries, evolving diagnostic programs have insufficient resources to either fully implement BI-RADS or to periodically evaluate the program's performance, which is a necessary component of BI-RADS. This leads to inconsistent breast ultrasound interpretation and a failure to improve performance.
Methods:
The authors applied the Breast Health Global Initiative's phased implementation strategy to implement diagnostic ultrasound and BI-RADS within the context of a limited-resource setting.
Results:
The authors recommended starting with triage ultrasound to distinguish suspicious masses from normal breast tissue and benign masses such as cysts because the majority of health workers performing ultrasounds at this level have minimal breast imaging experience. Transitioning to full diagnostic ultrasound with condensed or full BI-RADS should occur after performance and quality metrics have been met.
Conclusions:
Transitioning through these phases across facilities likely will occur at different times, particularly in rural versus urban settings.
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