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Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

Association between hyperglycemia and the malignant transformation of oral leukoplakia in China

Jin Li^1,2, Yang Liu¹, Hua Zhang³

¹Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China.

|April 30, 2020

Abstract

Objectives:

This study aimed to examine the association between hyperglycemia and the malignant transformation of oral leukoplakia (OLK).

Patients And Methods:

This retrospective case-control study involved 133 patients with the malignant transformation of OLK into oral squamous cell carcinoma (case group) and 266 patients with untransformed OLK (control group). The clinical history and follow-up data included age, gender, lesion size and location, and fasting plasma glucose. Logistic regression analysis, Kaplan-Meier survival analysis, and univariate and multivariate Cox regression analyses were used to assess the effects of risk factors on the malignant transformation of OLK.

Results:

Hyperglycemia (adjusted hazard ratio [AHR] = 4.7, p = .001), non-homogenous OLK (AHR = 3.0, p < .001), location of the lesion on the ventral surface of the tongue or floor of the mouth (AHR = 3.6, p < .001), and epithelial dysplasia (AHR = 2.8, p = .005) had significant effects on the malignant transformation of OLK.

Conclusion:

Hyperglycemia, non-homogenous OLK, location of the lesion on the ventral surface of the tongue or floor of the mouth, and epithelial dysplasia might be associated with malignant transformation of OLK.

Keywords:

diabetes mellitus head and neck cancer hyperglycemia oral cancer oral leukoplakia squamous cell carcinoma

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Keywords:

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