Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.

PLoS biology·2024
Same author

A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma.

Cell reports·2024
Same author

A novel mathematical template for developing fDOM probe fluorescence signal correction models for freshwaters.

Journal of environmental sciences (China)·2024
Same author

Effects of wind-driven current and thermal dynamics in a temperate monomictic reservoir: Implications for manganese transport and treatment in water supply systems.

Journal of environmental management·2024
Same author

A Simple and Scalable Zebrafish Model of Sonic Hedgehog Medulloblastoma.

bioRxiv : the preprint server for biology·2024
Same author

Catching nano: Evaluating the fate and behaviour of nano-TiO<sub>2</sub> in swimming pools through dynamic simulation modelling.

Journal of environmental management·2023

Related Experiment Video

Updated: Dec 23, 2025

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis
12:08

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

Published on: June 19, 2021

13.6K

Pediatric Cancer Models in Zebrafish.

Mattie J Casey1, Rodney A Stewart1

  • 1Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Trends in Cancer
|April 30, 2020
PubMed
Summary

Zebrafish models offer unique advantages for studying pediatric cancers, aiding in the discovery of new treatment mechanisms and drug targets for childhood leukemias, neural tumors, and sarcomas.

Keywords:
brain tumorscancerleukemiapediatricsarcomazebrafish

More Related Videos

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response
09:43

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Published on: May 17, 2017

12.0K
Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.1K

Related Experiment Videos

Last Updated: Dec 23, 2025

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis
12:08

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

Published on: June 19, 2021

13.6K
Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response
09:43

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Published on: May 17, 2017

12.0K
Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.1K

Area of Science:

  • Developmental biology
  • Cancer research
  • Genetics and epigenetics

Background:

  • Pediatric cancer remains a significant cause of mortality in children and adolescents.
  • Understanding the genetic, epigenetic, and developmental drivers of pediatric cancers is crucial for improving treatments and reducing long-term adverse effects.

Purpose of the Study:

  • To review the utility of the zebrafish model system in pediatric cancer research.
  • To highlight how zebrafish attributes facilitate the identification of novel mechanisms in tumor initiation, progression, and relapse.
  • To discuss the application of zebrafish models in pediatric cancer drug discovery.

Main Methods:

  • Utilizing the zebrafish model system for its strengths in embryology, high-resolution imaging, and scalability.
  • Developing and employing zebrafish models for specific pediatric cancers, including leukemias, neural tumors, and sarcomas.
  • Investigating tumor initiation, progression, and relapse mechanisms within these zebrafish models.

Main Results:

  • Zebrafish models have proven effective in uncovering new insights into the fundamental biology of pediatric cancers.
  • The scalability and imaging capabilities of zebrafish facilitate high-throughput screening for potential therapeutic compounds.
  • Specific zebrafish models have been instrumental in understanding the development of common and challenging childhood cancers.

Conclusions:

  • The zebrafish model system provides a powerful and versatile platform for advancing pediatric cancer research.
  • Continued use of zebrafish models is expected to accelerate the discovery of novel therapeutic strategies and improve outcomes for children with cancer.
  • Zebrafish research contributes significantly to understanding the genetic and developmental underpinnings of pediatric leukemias, neural tumors, and sarcomas.