Related Experiment Video
Updated: Dec 23, 2025
04:37
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
938
Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis
Zhijia Fan1, Li Wang1, Haoqin Jiang1
1Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Dermatology (Basel, Switzerland)
|April 30, 2020
Summary
Psoriasis involves immune system inflammation and increased cardiovascular risk, linked to overactive platelets. This review explores abnormal platelet function in psoriasis pathogenesis for new treatment targets.
Area of Science:
- Dermatology
- Immunology
- Hematology
Background:
- Psoriasis is an immune-mediated inflammatory skin condition with systemic implications.
- Severe psoriasis correlates with elevated cardiovascular disease risks.
- Prothrombotic state in psoriasis involves disrupted hemostatic balance, primarily due to platelet hyperactivity.
Purpose of the Study:
- To review abnormal platelet function in psoriasis.
- To elucidate the role of platelets in psoriasis pathogenesis.
- To identify novel therapeutic targets for psoriasis treatment.
Main Methods:
- Literature review of studies on psoriasis and platelet function.
- Analysis of research on platelet hyperactivity and immune roles.
- Synthesis of evidence linking platelet dysfunction to psoriasis mechanisms.
Main Results:
- Platelets act as immune cells, regulating inflammatory processes.
- Platelet hyperactivity contributes to the prothrombotic state in psoriasis.
- Platelet dysfunction is integral to the pathogenesis of psoriasis.
Conclusions:
- Abnormal platelet function is a key feature of psoriasis.
- Understanding platelet roles offers new avenues for comprehensive psoriasis management.
- Targeting platelet pathways may provide novel therapeutic strategies.
Related Concept Videos
01:22Formation of the Platelet Plug
8.4K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.4K
01:18Structure and Function of Platelets
2.6K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.6K
01:24Disorders of Hemostasis
1.8K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.8K
01:30Peripheral Artery Disease I: Introduction
222
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
222
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.4K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.4K
01:16Clot Retraction and Fibrinolysis
8.1K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.1K