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Potential therapeutic treatments of cancer-induced bone pain

Holly M Ellingson1, Todd W Vanderah

  • 1Department of Medical Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA.

Current Opinion in Supportive and Palliative Care
|April 30, 2020
PubMed
Abstract

Insights

New therapeutic targets show promise for treating cancer-induced bone pain (CIBP). These novel approaches, including the cysteine/glutamate antiporter system (x c), avoid the negative side effects associated with opioid use.

Area of Science:

  • Oncology
  • Pain Management
  • Pharmacology

Background:

  • Cancer-induced bone pain (CIBP) affects a significant portion of cancer patients.
  • Current treatments, primarily opioids, are often ineffective and carry substantial side effects.
  • There is a critical need for alternative, effective pain management strategies.

Purpose of the Study:

  • To review recent advancements in potential novel therapeutic targets for CIBP.
  • To explore alternative pathways beyond traditional opioid analgesics.
  • To highlight promising preclinical findings in CIBP treatment.

Main Methods:

  • Review of recent scientific literature focusing on CIBP.
  • Analysis of preclinical studies, particularly in murine models.
  • Investigation of alternative therapeutic targets and receptor pathways.

Main Results:

  • The cysteine/glutamate antiporter system (x c) shows therapeutic potential.
  • Cannabinoids and kappa opioids are identified as promising targets.
  • A ceramide axis, including sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1, is explored for pain relief.

Conclusions:

  • Novel therapeutic targets offer a promising alternative to opioids for CIBP.
  • Targeting systems like x c, cannabinoids, kappa opioids, and the ceramide axis may provide effective pain management.
  • Further research into these pathways could lead to improved CIBP treatments.

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