Polybrominated dibenzo-p-dioxins (PBDDs) and - dibenzofurans (PBDFs) in cod (Gadus morhua) liver-derived products...

Literature data on the occurrence and prevalence of polybrominated dibenzo-p-dioxins (PBDDs) and polybrominated dibenzofurans (PBDFs) in foods including seafood are scarce. In this study, a number of cod-derived products including medicinal grade cod liver oils sourced from Northern Atlantic waters (Iceland, Norway) and the Baltic Sea (Poland) during 1972-2001 and canned cod liver sourced from the Baltic Sea in 2017, showed detectable levels of PBDFs: such as 2,3,8-TrBDF at 0.57 to 5.249 pg g^-1 fat and 1,2,3,4,6,7,8-HpBDF at <0.018 to 0.302 pg g^-1 fat. PBDDs were not detected in the cod liver oils. Canned cod liver products showed low levels of 2,3,7,8-TeBDD in the range <0.017 to 0.022 pg g^-1 whole weight and 1,2,3,7,8-PeBDD at <0.03 to 0.039 pg g^-1 whole weight. These concentrations were computed to yield upper bound toxic equivalences (TEQs) of 0.14 to 0.17 pg g^-1 for the oils and 0.12 to 0.25 pg g^-1 for the canned products (0.08 pg g^-1 ww for both products). The resulting supplementary and dietary intakes are low (0.02 to 0.11 pg kg^-1 bm day^-1 for the oils and 0.07 to 0.17 pg kg^-1 bm week^-1 for the canned livers) in comparison to the recently expressed tolerable weekly intake of 2 pg kg^-1 bm week^-1. However, the intakes are underestimates, as due to a lack of analytical standards not all PBDD/F TEQ contributing congeners could be included. The PBDD/F TEQ contributes to the cumulative toxicity arising from other contaminants such as chlorinated dioxins and polychlorinated biphenyls.