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Updated: Dec 23, 2025

Directed Evolution Method in Saccharomyces cerevisiae: Mutant Library Creation and Screening
Published on: April 1, 2016
Multicopper Oxidases in Saccharomyces cerevisiae and Human Pathogenic Fungi
Tanmoy Chakraborty1, Renáta Tóth1, Joshua D Nosanchuk2
1Department of Microbiology, University of Szeged, Kozep fasor, 6726 Szeged, Hungary.
Abstract:
Multicopper oxidases (MCOs) are produced by microscopic and macroscopic fungal species and are involved in various physiological processes such as morphogenesis, lignin degradation, and defense mechanisms to stress inducing environmental conditions as well as fungal virulence. This review will summarize our current understanding regarding the functions of MCOs present in Saccharomyces cerevisiae and in different human fungal pathogens. Of the two main MCO groups, the first group of MCOs is involved in iron homoeostasis and the second includes laccases. This review will also discuss their role in the pathogenesis of human fungal pathogens.
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