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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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From transformation to chronification of migraine: pathophysiological and clinical aspects

M Torres-Ferrús1, F Ursitti2, A Alpuente3

  • 1Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute (VHIR), Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. marttorr@vhebron.net.

The Journal of Headache and Pain
|May 1, 2020
PubMed

Insights

Chronic migraine develops from episodic migraine, involving complex biological changes. This review synthesizes evidence on factors contributing to migraine transformation into a chronic state.

Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Chronic migraine (CM) is defined as 15+ headache days/month, with 8+ days exhibiting migraine features.
  • Migraine transformation, or chronification, describes the progression from episodic to chronic migraine.
  • Understanding the pathological brain state of CM is crucial for effective treatment.

Purpose of the Study:

  • To comprehensively review existing evidence on factors influencing migraine transformation.
  • To explore the clinical, epidemiological, genetic, molecular, structural, functional, physiological, and preclinical aspects of CM.
  • To elucidate the biological changes associated with the development of chronic migraine.

Main Methods:

  • Systematic literature review of studies on migraine transformation.
  • Analysis of clinical and epidemiological data.
  • Evaluation of genetic, molecular, structural, functional, physiological, and preclinical research.

Main Results:

  • Identified multiple factors contributing to migraine chronification from diverse scientific fields.
  • Highlighted the trigeminovascular system's role in the pathological brain state of CM.
  • Synthesized evidence indicating significant biological alterations in chronic migraine.

Conclusions:

  • Migraine transformation is a complex process influenced by various factors.
  • CM represents a pathological brain state with demonstrable biological changes.
  • Further research integrating multiple evidence types is needed to fully understand and treat chronic migraine.
Keywords:
Animal modelsBiomarkerChronic migraineGeneticsNeuroimagingNeurophysiologyPathophysiologyRisk factorsTransformation

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