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Updated: Dec 23, 2025
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Corneal epithelial thickness one year after myopic LASIK surgery, measured by anterior segment optical coherence
J Díaz-Bernal1, I García-Basterra1, J Mora-Castilla2
1Departamento de Oftalmología, Hospital Universitario Virgen de la Victoria, Málaga, España.
Objective:
To compare corneal epithelial thickness (CET) between patients who underwent LASIK surgery for the correction of myopia at least one year ago and healthy subjects.
Methods:
A retrospective observational study was conducted that included 93 healthy subjects (186eyes) and 26 subjects (52eyes) that underwent myopic LASIK surgery. OCT-SA, combined with Placido disk, was performed on all subjects, and CET maps were measured. Statistical analysis was performed to analyse differences between groups. Multivariate analysis was also performed to look for possible predictors of final CET.
Results:
There was no statistically significant differences between the groups in the demographic (age, sex) or anterior segment parameters (spherical equivalent, pachymetry) (all P>.05). Statistically significant differences (P<.05) were obtained between both groups when comparing CET, including central, internal, and external rings (higher in patients that underwent LASIK surgery ≥1year). With the exception of the time elapsed since surgery (P=.00), no correlation was found between the CET and age, sex, ablated dioptres, or other variables studied (P<.05).
Conclusions:
CET values measured by the OCT-SA were higher in patients that underwent LASIK surgery ≥1year. The only variable that correlated with the CET after LASIK was the time elapsed since surgery. CET changes should be taken into consideration when planning refractive surgery due to its implications on the final outcome.
