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Updated: Dec 23, 2025

An Ex vivo Model to Study Hormone Action in the Human Breast
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Progesterone and breast.

Caroline A Lamb1, Victoria T Fabris1, Claudia Lanari1

  • 1Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490 1428, Buenos Aires, Argentina.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|May 1, 2020
PubMed
Summary
This summary is machine-generated.

Progesterone, a key pregnancy hormone, plays a crucial role in human breast development and cancer. Understanding its mechanisms offers potential therapeutic strategies for breast cancer treatment.

Keywords:
BreastBreast cancerProgesteroneProgesterone receptorProgesterone receptor isoformsProgestins

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Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Oncology

Background:

  • Progesterone (Pg) is vital for pregnancy, preparing the endometrium and suppressing uterine contractions.
  • It also acts as an immunosuppressant, preventing fetal rejection.
  • Its specific functions in the human breast, particularly in development and cancer, require further elucidation.

Purpose of the Study:

  • To explore the role of progesterone in normal human breast development.
  • To investigate the involvement of progesterone in breast cancer.
  • To review therapeutic strategies involving progestins and antiprogestins in breast cancer treatment.

Main Methods:

  • Review of existing literature on progesterone's effects in the mammary gland.
  • Analysis of progesterone's role in breast cancer risk and progression.
  • Description of current clinical trials involving progestins and antiprogestins.

Main Results:

  • Progesterone influences normal breast development.
  • Progesterone signaling pathways are implicated in breast cancer.
  • Clinical trials are exploring progestin-based therapies for breast cancer.

Conclusions:

  • Progesterone significantly impacts both normal and neoplastic mammary gland.
  • Targeting progesterone signaling pathways presents a promising therapeutic avenue for breast cancer.
  • Further research and clinical trials are essential to optimize progestin-based treatments.