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Related Experiment Video

Updated: Dec 23, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension.

Xiao-Fei Mei1, Sheng-Da Hu1, Peng-Fei Liu1

  • 1Department of Cardiology, The First Affiliated Hospital of Soochow University.

International Heart Journal
|May 1, 2020
PubMed
Summary
This summary is machine-generated.

The Aldehyde dehydrogenase-2 (ALDH2) rs671 G>A polymorphism may reduce essential hypertension (EH) risk, particularly in males. This genetic variant presents potential for EH therapeutic strategies.

Keywords:
AssociationMeta-analysisSingle nucleotide polymorphism

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Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • The Aldehyde dehydrogenase-2 (ALDH2) rs671 G>A polymorphism's association with essential hypertension (EH) risk remains controversial.
  • Previous studies have yielded conflicting results regarding the ALDH2 gene's role in EH susceptibility.

Purpose of the Study:

  • To conduct a meta-analysis investigating the relationship between ALDH2 rs671 polymorphism and essential hypertension risk.
  • To clarify the association by analyzing data from multiple studies and performing subgroup analyses.

Main Methods:

  • Systematic literature search of PubMed, Embase, and China National Knowledge Infrastructure databases for studies on ALDH2 and EH.
  • Meta-analysis of 12 studies (8153 cases, 10,162 controls) using odds ratios and 95% confidence intervals.
  • Quality assessment using the Newcastle-Ottawa Scale, subgroup analysis, sensitivity analysis, and publication bias assessment.

Main Results:

  • Significant association found between ALDH2 rs671 polymorphism and EH across allele, homozygote, heterozygote, and dominant genetic models.
  • No significant association in the recessive model, but a trend towards decreased risk was observed.
  • A stronger association was noted between rs671 mutation and EH risk in males compared to females across all models.

Conclusions:

  • ALDH2 rs671 G>A polymorphism appears to decrease the risk of essential hypertension.
  • EH susceptibility is reduced in males, but not significantly in females, with this polymorphism.
  • The ALDH2 rs671 G>A variant is a potential candidate for genetic therapy of EH, warranting further research on gene-gene and gene-environment interactions.