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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

648
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
648
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

665
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
665
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

136
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
136
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.3K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.3K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

139
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
139
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.4K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Updated: Dec 22, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Functional peptide-based drug delivery systems.

Zheng Lian1, Tianjiao Ji

  • 1People's Public Security University of China, Beijing 100038, China.

Journal of Materials Chemistry. B
|May 1, 2020
PubMed
Summary
This summary is machine-generated.

Functional peptides are key for smart drug delivery systems (DDSs), enabling targeted and responsive delivery. This review covers peptide types, design strategies, challenges, and future prospects for peptide-based DDSs.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery
  • Peptide Chemistry

Background:

  • Peptides serve as crucial functional motifs in developing advanced drug delivery systems (DDSs).
  • Their ability to conjugate with drugs/carriers or self-assemble facilitates targeted and stimuli-responsive DDS functionalities.

Purpose of the Study:

  • To review common functional peptides used in constructing drug delivery systems.
  • To highlight recent strategies for designing smart DDSs utilizing functional peptides.
  • To discuss current challenges and future prospects of peptide-based DDSs.

Main Methods:

  • Literature review of functional peptides in drug delivery.
  • Analysis of conjugation and self-assembly strategies for DDS construction.
  • Identification and discussion of challenges and future directions.

Main Results:

  • Overview of diverse functional peptide types applicable to DDS.
  • Presentation of representative design strategies for peptide-based smart DDSs.
  • Identification of key challenges and promising future research avenues.

Conclusions:

  • Functional peptides are versatile building blocks for sophisticated drug delivery systems.
  • Strategic design enables peptides to impart targeting and responsiveness to DDS.
  • Addressing current challenges will unlock the full potential of peptide-based DDSs.