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Updated: Dec 22, 2025

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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Published on: August 13, 2013

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Transcriptional regulation of Treg homeostasis and functional specification

Ke Wang1, Wenxian Fu2,3

  • 1Pediatric Diabetes Research Center, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

Cellular and Molecular Life Sciences : CMLS
|May 1, 2020
PubMed

CD4+Foxp3+ regulatory T (Treg) cells are key players in keeping excessive inflammation in check. Mounting evidence has shown that Treg cells exert much more diverse functions in both immunological and non-immunological processes. The development, maintenance and functional specification of Treg cells are regulated by multilayered factors, including antigens and TCR signaling, cytokines, epigenetic modifiers and transcription factors (TFs). In the review, we will focus on TFs by summarizing their unique and redundant roles in Treg cells under physiological and pathophysiological conditions. We will also discuss the recent advances of Treg trajectories between lymphoid organs and non-lymphoid tissues. This review will provide an updated view of the newly identified TFs and new functions of known TFs in Treg biology.

Keywords:
CofactorHomeostasisLEF1PrecursorTCF1Treg

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