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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Lipids: Dietary Sources and Requirements01:18

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Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
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Updated: Dec 22, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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LDL-Cholesterol-Lowering Therapy.

Angela Pirillo1,2, Giuseppe D Norata3,1, Alberico L Catapano4,5

  • 1Center for the Study of Atherosclerosis, E. Bassini Hospital, Milan, Italy.

Handbook of Experimental Pharmacology
|May 1, 2020
PubMed
Summary
This summary is machine-generated.

Elevated LDL-C causes cardiovascular disease, making LDL-C reduction key for prevention. New drugs offer alternatives or complements to statins for managing residual cardiovascular risk.

Keywords:
Cardiovascular diseaseDyslipidemiasEzetimibeFamilial hypercholesterolemiaHypercholesterolemiaHypertriglyceridemiaLipid-lowering drugsLow-density lipoprotein cholesterolLow-density lipoprotein receptorProprotein convertase subtilisin/kexin type 9Statins

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Lipid Metabolism

Background:

  • Established link between high low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD).
  • Statins are primary therapy for lowering LDL-C, but residual CVD risk persists.
  • Need for alternative or adjunctive lipid-lowering therapies due to statin intolerance and residual risk.

Purpose of the Study:

  • To review the role of LDL-C in cardiovascular disease.
  • To discuss the limitations of statin therapy.
  • To explore novel lipid-lowering drugs with different mechanisms or targets.

Main Methods:

  • Review of experimental and clinical studies on LDL-C and CVD.
  • Analysis of therapeutic strategies for lipid management.
  • Examination of recently approved lipid-lowering agents.

Main Results:

  • Confirmation of LDL-C as a major cardiovascular risk factor.
  • Identification of residual lipid-related risk despite statin use.
  • Emergence of new drugs targeting different lipoproteins or pathways.

Conclusions:

  • Reducing LDL-C remains a critical goal in cardiovascular disease prevention.
  • New pharmacological options are available for patients needing alternatives or additions to statins.
  • These advancements address unmet needs in managing hyperlipidemia and reducing cardiovascular risk.