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Xenon-133 determination of muscle blood flow in electrical injury
Abstract:
Xe-133 washout determination of muscle blood flow (MBF) was used to detect muscle ischemia in electrical injury of an experimental animal model and three patients. The control MBF of rabbit hindlimbs, which averaged 11.29 +/- 1.07 cc/min/100 gm, was significantly reduced by electrical injury, to 5.82 +/- 1.49 cc/min/100 gm (p less than 0.001). An electrical injury of 4,000 watt-seconds or greater was associated with uniform MBF less than 1.00 cc/min/100 gm and with histopathologic alterations of muscle necrosis. Thenar MBF less than 1.00 cc/min/100 gm in two patients was associated with muscle necrosis requiring distal arm amputation. The remaining patient with sequential muscle blood flows above this level had uneventful healing of hand electrical injuries. Xe-133 determination of MBF may be a useful objective technique to determine the extent of electrical injury in muscle.
Insights
Xenon-133 washout measurement of muscle blood flow (MBF) effectively detects muscle ischemia from electrical injuries. Low MBF values correlate with severe muscle damage and amputation, aiding in injury assessment.
Area of Science:
- Biomedical Engineering
- Physiology
- Trauma Surgery
Background:
- Electrical injuries pose significant risks of muscle damage and ischemia.
- Assessing the extent of muscle blood flow (MBF) is crucial for predicting outcomes.
- Current methods for evaluating muscle ischemia may lack objectivity.