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MicroRNAs in atopic dermatitis: A systematic review.
Xin Yu1, Meifang Wang1, Linfeng Li1
1Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Journal of Cellular and Molecular Medicine
|May 1, 2020
Summary
MicroRNAs (miRNAs) play a key role in atopic dermatitis (AD) pathogenesis. This review highlights how miRNA deregulation impacts skin inflammation and immune responses in AD.
Area of Science:
- Immunology
- Genetics
- Dermatology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition with unclear molecular mechanisms.
- MicroRNAs (miRNAs) are regulators of gene expression involved in inflammatory skin diseases.
Purpose of the Study:
- To systematically review the role of miRNAs in the development of atopic dermatitis.
- To summarize current findings on miRNA dysregulation in AD pathogenesis.
Main Methods:
- Systematic literature search of PubMed and Web of Science databases.
- Inclusion of observational and experimental studies on miRNAs and AD up to January 2020.
Main Results:
- Dysregulation of specific miRNAs (e.g., miR-143, miR-146a) observed in AD patients.
- Experimental studies confirm miRNA roles in keratinocyte function, inflammation, and immune cell activity (Th17, Treg).
Conclusions:
- miRNA deregulation significantly contributes to the pathogenesis of atopic dermatitis.
- Understanding miRNA roles offers potential therapeutic targets for AD.
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