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Antithrombotic Treatment in Cardiomyopathies

Georgia Vogiatzi1, Antonios Pantazis2, Dimitris Tousoulis1

  • 1First Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Current Pharmaceutical Design
|May 1, 2020
PubMed

Insights

Cardiomyopathies, a cause of heart failure, have unclear antithrombotic therapy benefits for preventing blood clots. More research is needed to determine the risk-benefit ratio for these patients.

Area of Science:

  • Cardiology
  • Thrombosis Research

Background:

  • Cardiomyopathies are a diverse group of heart muscle diseases leading to heart failure.
  • Existing evidence on heart failure in cardiomyopathies is growing, but therapeutic strategies require clarification.

Purpose of the Study:

  • To review epidemiologic, pathophysiologic, clinical, and therapeutic data on thromboembolism prevention in heart failure due to cardiomyopathies.
  • To address the lack of consensus regarding antithrombotic therapy in cardiomyopathies without primary valvular disease or atrial fibrillation.

Main Methods:

  • This is a review article.
  • It synthesizes existing data on thromboembolism in cardiomyopathies.

Main Results:

  • Observational data suggest an increased venous thromboembolic risk in cardiomyopathies.
  • The precise role and risk:benefit ratio of antithrombotic therapy remain unclear in this patient population.

Conclusions:

  • Antithrombotic therapy's efficacy in preventing thromboembolic events in cardiomyopathies without atrial fibrillation or valvular disease is not established.
  • Further investigation is warranted to guide therapeutic decisions for thromboembolism prevention in heart failure patients with cardiomyopathies.

Keywords:
Cardiomyopathiesanti-plateletsanticoagulationantithromboticheart failurethromboembolism

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