Related Experiment Video
Updated: Dec 22, 2025
04:13
Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
Published on: September 27, 2024
706
Osteonecrosis Mandibular Extended to Bisphosphonates: A Very Rare Extensive Case.
Lahcen Khalfi1, Abibou Ndiaye2, Wilfried Chabi1
1Plastic and Maxillo-Facial Surgery, Mohammed V Teaching Armed Forces Hospital, Rabat, MAR.
Cureus
|May 1, 2020
Summary
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is increasing. This case details extensive mandibular necrosis and a conservative surgical approach using a titanium plate for reconstruction.
Area of Science:
- Oral and Maxillofacial Surgery
- Oncology
- Pharmacology
Background:
- Bisphosphonate-related osteonecrosis of the jaw (BRONJ) incidence has risen since its 2003 identification.
- BRONJ presents a significant clinical challenge due to its increasing prevalence.
Observation:
- A rare, extensive case of BRONJ involving bone exposure and necrosis extending to the mandibular inferior border is presented.
- This case represents an unprecedented severity in the authors' clinical experience.
Findings:
- Conservative surgical management is recommended for BRONJ, though treatment modalities remain under investigation.
- The surgical approach involved conservative resection of the affected mandibular segment.
- Reconstruction utilized a titanium plate and space maintainer to restore mandibular integrity.
Implications:
- Sharing this extensive case and management approach can enhance clinical awareness and guide future BRONJ treatment strategies.
- This case highlights the importance of conservative surgical techniques in managing severe BRONJ.
- Further research into established treatment protocols for BRONJ is warranted to improve patient outcomes.
Related Concept Videos
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:31Osteoclasts in Bone Remodeling
3.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.7K
01:02What is the Skeletal System?
56.2K
Overview
56.2K
01:40Bone Remodeling
40.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.1K
01:31Essential Minerals for Bone Health
5.7K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.7K
01:18The Bone Matrix
5.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.3K