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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Core-shell particles for drug-delivery, bioimaging, sensing, and tissue engineering.

Ratchapol Jenjob1, Treethip Phakkeeree, Daniel Crespy

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Core-shell nanoparticles offer advanced drug delivery and bioimaging solutions. This review details their design, biomedical applications, and use in diagnostics like MRI and PET imaging.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Core-shell nanoparticles are versatile nanomaterials with diverse applications.
  • Their unique structure offers advantages for protecting sensitive payloads and enabling controlled release.
  • These nanoparticles are increasingly investigated for biomedical uses, including drug delivery and diagnostics.

Purpose of the Study:

  • To review state-of-the-art techniques for designing core-shell nanoparticles for biomedical applications.
  • To present recent advances in drug, protein/peptide, and gene delivery using core-shell nanoparticles.
  • To highlight the utility of core-shell particles in various bioimaging modalities and as biosensors.

Main Methods:

  • Review of current literature on core-shell nanoparticle design and synthesis.
  • Analysis of studies focusing on the application of core-shell nanoparticles in drug, protein/peptide, and gene delivery.
  • Examination of research on core-shell nanoparticles for bioimaging (MRI, PET, CT, ultrasound, optical) and biosensing.

Main Results:

  • Core-shell nanoparticles facilitate sequence-controlled drug release and payload protection.
  • Successful preclinical investigations demonstrate their potential in delivering drugs, peptides, and hormones.
  • Core-shell particles show promise as contrast agents and labels for multiple bioimaging techniques.

Conclusions:

  • Core-shell nanoparticles represent a significant advancement in nanomedicine.
  • Their design flexibility and functional versatility make them highly suitable for diverse biomedical applications.
  • Further research and development in core-shell nanoparticle technology will drive innovation in targeted therapies and diagnostics.