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Phase Diagram Characterization Using Magnetic Beads as Liquid Carriers

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Microvolume Screening of Extraction and Phase Behavior in a Liquid-Liquid Microsystem.

Claudia Binder¹, Benjamin Lageder¹, Bronwyn H Bradshaw-Hajek²

¹Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia.

Analytical Chemistry

|May 1, 2020

Summary

A new microfluidic method tracks third-phase formation during solvent extraction in real-time. This technique aids in developing new reagents and understanding complex chemical processes.

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Area of Science:

Chemical Engineering
Materials Science
Analytical Chemistry

Background:

Third-phase formation during liquid-liquid solvent extraction poses significant industrial challenges.
Current methods lack the ability to simultaneously monitor extraction progress, third-phase onset, and the chemical/physical properties of the phases.
Understanding complex phase behavior is crucial for optimizing extraction processes.

Purpose of the Study:

To introduce a novel microfluidic strategy for real-time analysis of third-phase formation in solvent extraction.
To correlate the visual onset of third-phase formation with extraction efficiency and loading limits.
To enable spectroscopic characterization of the formed third phase.

Main Methods:

Development of a microfluidic device featuring a submicroliter organic-phase film within a micropillar array.
Extraction of Ytterbium (Yb3+) and Dysprosium (Dy3+) using 1 M Cyanex 572 in Shellsol D70 from an acidic aqueous phase.
Real-time optical tracking of phase behavior and spectroscopic analysis of the third phase.

Main Results:

The microfluidic setup successfully supported an optically transparent organic film.
Real-time optical tracking demonstrated that third-phase formation coincides with the cessation of metal ion extraction.
Spectroscopic analysis provided insights into the chemical and physical nature of the solid-like third phase.

Conclusions:

The presented microfluidic approach offers a significant advancement for studying reactive multiphase systems.
This method enhances the speed and efficiency of reagent development and process control in solvent extraction.
It provides a powerful tool for fundamental investigations into complex phase behavior.