Changes of manganese levels during haemodialysis

Manganese (Mn) transfer during haemodialysis and plasma Mn concentrations in haemodialysis patients were examined. Also, the correlation with plasma Mn levels and haematocrit levels and total plasma protein levels were studied. Fifteen volunteer outpatients undergoing haemodialysis showed significant increases in plasma Mn from 0.20 +/- 0.02 to 0.22 +/- 0.02 micrograms/dl after a 5-hour dialysis. The increase was mainly the result of haemoconcentration as evidenced by a significant increase in the haematocrit and total plasma protein during dialysis; however, diffusion was not found. There was a significant relationship between plasma Mn levels before dialysis and haematocrit values (r = 0.95, p less than 0.01) and total plasma protein levels (r = 0.92, p less than 0.01).