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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Invasive aspergillosis in a patient with aplastic anemia receiving amphotericin B
G A Antoine1, R H Gates, A O Park
1Department of Surgery, Tripler Army Medical Center, Honolulu, Hawaii 96859-5000.
Abstract:
Invasive mycotic infections are becoming more commonplace in immune-compromised hosts. Aspergillus species is the most commonly encountered fungal genus in our environment causing paranasal sinus fungal infection. Aspergillus paranasal sinus infections in the healthy host are readily treated and controlled. In the immune-compromised host this common organism can rapidly become fatal even if recognized and treated appropriately. We present a case history of a patient who died from her disease despite radical surgery and antifungicidal therapy. Recent methods for early diagnosis will be reviewed. Only one other case has been reported in the literature of a patient developing fulminant aspergillosis sinusitis while receiving amphotericin B.
Insights
Invasive fungal infections, particularly Aspergillus sinusitis, are dangerous in immunocompromised patients. This case highlights a fatal outcome despite aggressive treatment, emphasizing the need for early diagnosis methods.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Immunocompromised Host Research
Background:
- Invasive mycotic infections are increasing in immunocompromised individuals.
- Aspergillus species are common environmental fungi causing paranasal sinus infections.
- While treatable in healthy hosts, Aspergillus sinusitis can be fatal in immunocompromised patients.
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