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Updated: Dec 22, 2025

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
Published on: November 5, 2016
Controllable antibacterial and bacterially anti-adhesive surface fabricated by a bio-inspired beetle-like
Jing Lin1, Yufei Wang1, Xingchuan Wei1
1School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, PR China.
Abstract:
Drug resistance to bacteria becomes an emerging intractable problem, therefore, developing novel antibacterial agents has become urgently needed. Herein, a bio-inspired design strategy was adopted to synthesize a series of beetle-like macromolecule of multiple quaternary ammonium salts (QASs), which was designed with different cationic charge densities and numbers of hexadecane chains by adjusting their different quaternization degree (QD). It was found that the fabricated fabric surface with them exhibited controllable and outstanding antibacterial and bacterially anti-adhesive properties. More importantly, the antibacterial efficiency was demonstrated to be enhanced with the increasing of QD, and related to the zeta potential, and surface tension. Additionally, the proposed bacterially anti-adhesive model of action revealed the "resisting effect" of hydration layer which greatly resisted the adhesion of bacteria.
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