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Development of complex renal cysts: A complication associated with Crizotinib therapy
Frank Chen1, Neema J Patel1, Jordan D Legout1
1Department of Radiology, Mayo Clinic, Jacksonville, FL, United States of America.
Clinical Imaging
|May 1, 2020
Summary
Crizotinib effectively treats anaplastic lymphoma kinase (ALK) positive lung cancer but can cause complex renal cysts. Recognizing this side effect is crucial to distinguish it from other serious kidney conditions.
Area of Science:
- Oncology
- Pharmacology
- Nephrology
Background:
- Crizotinib is a targeted therapy for anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer.
- It demonstrates superior efficacy compared to traditional chemotherapy in this patient subgroup.
Observation:
- A case report details a 68-year-old patient with non-small cell lung cancer undergoing Crizotinib treatment.
- This patient developed bilateral complex renal cysts during therapy.
Findings:
- Crizotinib therapy is associated with the development of complex renal cysts.
- These cysts can appear bilaterally.
Implications:
- Distinguishing Crizotinib-induced renal cysts from disease progression, primary renal malignancy, or infection is clinically important.
- Awareness of this adverse effect aids in accurate patient management and diagnosis.
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