Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.4K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.4K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

285
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
285
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

41.3K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.3K
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

2.2K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.2K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

3.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic insights into exercise-induced trabecular bone microarchitectural adaptations following combined aerobic and resistance training in mice.

Scientific reports·2026
Same author

Quantitative assessment of inspiratory loading on postprandial glycemia and metabolic response in healthy adults.

Scientific reports·2026
Same author

Effects of exercise modalities on cognitive and muscle function in older adults with cognitive impairment: a systematic review and meta-analysis.

Scientific reports·2026
Same author

Relationships between heart rate-based training load and running metrics in field hockey players.

The Journal of sports medicine and physical fitness·2026
Same author

Therapeutic potential of exerkines in neurodegenerative and mental disorders: a narrative review.

Frontiers in physiology·2026
Same author

Protein corona-guided delivery of dextran-PLGA NPs for enhanced dendritic cell uptake, maturation and improved cancer immunotherapy.

Journal of controlled release : official journal of the Controlled Release Society·2026

Related Experiment Video

Updated: Dec 22, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.5K

Re-Setting the Circadian Clock Using Exercise against Sarcopenia.

Youngju Choi1, Jinkyung Cho1, Mi-Hyun No2

  • 1Institute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, Korea.

International Journal of Molecular Sciences
|May 2, 2020
PubMed
Summary
This summary is machine-generated.

Disrupted circadian rhythms accelerate sarcopenia, the loss of muscle mass and function. Scheduled exercise can reset the body clock, offering a novel strategy to combat age-related muscle decline.

Keywords:
circadian rhythmexercisemitochondrial functionsarcopeniaskeletal muscle

More Related Videos

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.7K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.7K

Related Experiment Videos

Last Updated: Dec 22, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.5K
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.7K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.7K

Area of Science:

  • Gerontology
  • Chronobiology
  • Muscle Physiology

Background:

  • Sarcopenia, the age-related loss of muscle mass and function, is linked to adverse health outcomes.
  • Disruption of circadian rhythms, from shift work or lifestyle, is an emerging factor in sarcopenia development.
  • Molecular circadian clock and mitochondrial dysfunction are implicated in circadian disruption-induced sarcopenia.

Purpose of the Study:

  • To review the impact of circadian disruption on skeletal muscle loss and sarcopenia.
  • To highlight exercise timing as a therapeutic strategy for circadian disruption in skeletal muscle.

Main Methods:

  • Literature review on circadian rhythms, muscle metabolism, and sarcopenia.
  • Analysis of molecular mechanisms linking circadian disruption to muscle function.
  • Examination of exercise as a zeitgeber for the skeletal muscle clock.

Main Results:

  • Circadian rhythm disruption negatively affects skeletal muscle mass and function.
  • Exercise acts as a potent modulator of skeletal muscle metabolism.
  • Exercise can serve as a zeitgeber to reset the skeletal muscle clock in sarcopenia.

Conclusions:

  • Circadian disruption is a significant contributor to sarcopenia.
  • Scheduled exercise is a promising therapeutic strategy to mitigate sarcopenia by targeting circadian disruption.