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Updated: Dec 22, 2025

A Simplified Model for Heterotopic Heart Valve Transplantation in Rodents
Published on: September 21, 2021
Expandable Valves, Annuloplasty Rings, Shunts, and Bands for Growing Children
Eric N Feins1, Sitaram M Emani1
1Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Insights
Pediatric heart surgery requires devices that accommodate growth. Current options necessitate reoperations, but new growth-accommodating technologies are emerging for better pediatric cardiac care.
Area of Science:
- Pediatric Cardiac Surgery
- Biomedical Engineering
- Regenerative Medicine
Background:
- Congenital heart surgery must account for pediatric somatic growth.
- Existing pediatric valve repair lacks growth-accommodating prostheses, leading to reoperations.
- Implant sizing for shunts, conduits, and pathways must consider current and future growth.
Purpose of the Study:
- To define the clinical need for growth-accommodating devices in pediatric congenital heart surgery.
- To review current and emerging technologies for growth accommodation in this field.
Main Methods:
- Literature review of clinical needs and technological advancements.
- Characterization of established and preclinical growth-accommodating technologies.
Main Results:
- A significant unmet need exists for pediatric cardiac devices that accommodate somatic growth.
- Several growth-accommodating technologies are in preclinical development, with some reaching the clinical arena.
Conclusions:
- Developing growth-accommodating technologies is crucial to minimize reoperations in pediatric congenital heart surgery.
- These innovations promise improved long-term outcomes for children requiring cardiac procedures.
Abstract:
In congenital heart surgery, the surgeon must constantly consider how a palliative or corrective procedure could be impacted by the child's somatic growth. Within pediatric valve surgery, existing valve repair techniques lack growth-accommodating prostheses. Valve replacement options are fixed in size and unable to grow with the child, thus subjecting children to repeated valve reoperations. When creating a systemic-to-pulmonary artery shunt, replacing a branch pulmonary artery or conduit, creating an extracardiac Fontan pathway, or banding the pulmonary artery, the implant size must factor in both the child's current size and his or her anticipated growth. A variety of growth-accommodating technologies have been developed to fill this unmet need. Some devices have reached the clinical arena, while several are in preclinical development. The purpose of this review is to characterize the clinical need for growing device technology, and then review established and developing technologies for growth accommodation in congenital heart surgery.
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