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Elderly Patients With Single Brain Metastasis - Overall Survival After Surgery Plus Whole-Brain Irradiation and a
Dirk Rades1, Trang Nguyen2, Steven E Schild3
1Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
Background/Aim:
Elderly patients with a single brain metastasis likely benefit from personalized treatment protocols. To add to treatment personalization, a survival score was generated for these patients.
Patients And Methods:
This retrospective study included 36 elderly patients, each with a single brain metastasis, who received surgery followed by whole-brain irradiation and a radiation boost. Six pre-treatment characteristics were evaluated regarding survival, namely age, gender, Karnofsky performance score (KPS), type of primary tumor, non-cerebral metastasis and interval from diagnosis of the neoplasm until surgery.
Results:
When applying the Cox regression model, KPS (p=0.005) and tumor type (p=0.018) were significant and incorporated in the score. Based on 12-month survival probabilities, three groups of 6-9 (n=5), 10-11 (n=15) and 14-19 points (n=16) were formed, with 12-month survival rates of 0%, 33% and 100%, respectively (p<0.0001).
Conclusion:
A survival score was generated specifically for elderly patients with a single brain metastasis that can improve personalization of their treatment.
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