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A Randomized Control Trial of Oral Sucrose Solution for Prevention of Hypoglycemia in High Risk Infants

Sarivirin Surachaidungtavil1, Pithi Chanvorachote2, Nithipun Suksumek3

  • 1Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand.

In Vivo (Athens, Greece)
|May 2, 2020
PubMed

Insights

Oral sucrose solution can increase glucose levels in high-risk newborns. However, early feeding alone is as effective as adding sucrose for preventing neonatal hypoglycemia.

Area of Science:

  • Neonatology
  • Pediatrics
  • Endocrinology

Background:

  • Neonatal hypoglycemia affects up to 15% of newborns, potentially causing developmental delays.
  • Limited data exist on preventing neonatal hypoglycemia with oral sucrose.
  • This study investigates oral sucrose for hypoglycemia prevention in high-risk infants.

Purpose of the Study:

  • To determine if oral sucrose solution can prevent hypoglycemia in high-risk infants.
  • To compare the efficacy of oral sucrose plus enteral feeding versus enteral feeding alone.

Main Methods:

  • 425 high-risk infants were randomized into intervention (oral sucrose + enteral feed) and control (enteral feed alone) groups.
  • The intervention group received a single dose of 0.8 ml/kg of 24% oral sucrose solution.
  • Glucose levels were monitored using Dextrostrix.

Main Results:

  • No significant differences in antenatal/perinatal risk factors or initial glucose levels between groups.
  • While overall glucose levels showed no significant difference, the sucrose group had a significantly higher glucose increase at 1, 3, and 6 hours.
  • No serious adverse events were reported in either group.

Conclusions:

  • A single dose of 24% oral sucrose solution enhances glucose level increases in newborns.
  • Routine early feeding alone is not inferior to adding oral sucrose for hypoglycemia prevention.
Abstract

Keywords:
24% Oral sucrose solutionearly feedinghigh-risk infantsneonatal hypoglycemia

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