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Updated: Dec 22, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Renal Squamous Cell Carcinoma with Staghorn Calculus
Ryo Kasahara1, Takashi Kawahara2, Ryosuke Tajiri3
1Department of Urology, Fujisawa City Hospital, Fujisawa, Japan.
A rare case of renal squamous cell carcinoma (SCC) was found alongside xanthogranulomatous inflammation in a patient treated for pyelonephritis. The aggressive cancer recurred locally shortly after surgery, leading to palliative care and the patient's death.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- A 70-year-old woman presented with fatigue and low-grade fever.
- Initial treatment focused on pyelonephritis secondary to a staghorn calculus, involving percutaneous nephrostomy and antibiotics.
Observation:
- Following infection control and nephrectomy, pathological examination revealed renal squamous cell carcinoma (SCC) co-existing with xanthogranulomatous inflammation.
- Post-operative computed tomography (CT) scan detected local tumor recurrence within 17 days.
Findings:
- The patient had aggressive renal SCC.
- Rapid local recurrence post-nephrectomy was observed.
Implications:
- This case highlights the importance of considering rare malignancies in complex renal presentations.
- Early detection and management strategies for renal SCC require further investigation, especially when associated with chronic inflammation.
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