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Related Concept Videos

Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

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Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time01:02

Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

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When drugs are administered extravascularly, a comprehensive evaluation through noncompartmental analysis becomes imperative. This analytical approach considers various parameters that play a crucial role in understanding the pharmacokinetics of these drugs.
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...
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Lower GI Series: Barium Enema01:23

Lower GI Series: Barium Enema

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A Barium Enema, or a lower GI series, is a specialized radiographic examination designed to visualize the lower gastrointestinal tract, specifically the colon and rectum. This procedure is instrumental in diagnosing various conditions such as colorectal cancer, polyps, diverticulosis, and inflammatory bowel disease.
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
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Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

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Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
507
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Related Experiment Video

Updated: Dec 22, 2025

Studying Murine Small Bowel Mechanosensing of Luminal Particulates
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Variation in small bowel transit time on capsule endoscopy.

Kentaro Tominaga1, Hiroki Sato1, Hiroshi Yokomichi2

  • 1Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan.

Annals of Translational Medicine
|May 2, 2020
PubMed
Summary

Small bowel transit time (SBTT) is longer in older adults and those with small bowel stenosis. Capsule endoscopy (CE) findings for SBTT require careful interpretation due to individual variations.

Keywords:
Agingcapsule endoscopy (CE)retentionsmall bowel transit time (SBTT)stenosis

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Area of Science:

  • Gastroenterology
  • Medical Imaging
  • Digestive System Physiology

Background:

  • Small bowel motility is complex and poorly understood.
  • Anatomical position and diverse functions contribute to this complexity.

Purpose of the Study:

  • Investigate small bowel transit time (SBTT) using capsule endoscopy (CE).
  • Analyze clinical factors influencing SBTT and CE retention.

Main Methods:

  • Analysis of SBTT in patients undergoing small bowel CE.
  • Investigation of factors affecting SBTT and capsule retention.

Main Results:

  • Mean SBTT was 282.1±132.2 minutes in 336 patients completing CE.
  • Aging and small bowel stenosis significantly extended SBTT.
  • CE retention occurred in 13.3% of patients, associated with small bowel lesions.

Conclusions:

  • Aging and small bowel stenosis are linked to prolonged SBTT.
  • Intra-individual variations in SBTT necessitate cautious interpretation of CE results.