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Direct high-performance liquid chromatographic resolution of dihydropyridine enantiomers
E Delee1, I Jullien, L Le Garrec
1Recherche Syntex France, Leuville-sur-Orge, Montlhéry.
Journal of Chromatography
|October 21, 1988
Abstract:
A direct high-performance liquid chromatographic enantioseparation on a chiral stationary phase using a protein as chiral selector was achieved for some dihydropyridines with different structural groups (amine, amide, acid and hydroxyl groups). The protein involved was alpha 1-acid glycoprotein and the work was mainly carried out with an EnantioPac column. An improved version of this chiral column (Chiral-AGP) was compared with the previous one and gave interesting results.